Olive trees (Olea europaea) and their processed products, such as olive oil, play a major\nrole in the Mediterranean way of life. Their positive impact on human health is being intensely\ninvestigated. One research topic is the identification of new application areas of olive mill wastewater\n(OMWW). OMWW is characterized by the high content of polyphenols possessing many positive\nhealth effects. Thus, the phenol-enriched OMWW extract offers the potential for the treatment of skin\ndisorders and for cosmetic application. The aim of the present study was to evaluate cell viability\nand proliferation, the anti-inflammatory and anti-oxidative properties of a phenol-enriched OMWW\nextract on an immortal keratinocyte cell line (HaCaT cells). Moreover, the influence on the growth\nof various microorganisms was investigated; furthermore, the effects on normal human epidermal\nkeratinocytes (NHEK) and human melanoma cells (A375) were studied in a commercially available\ntumor invasion skin model. The phenol-enriched OMWW extract showed excellent antimicrobial\nactivity. Moreover, a noticeable reduction in reactive oxygen species formation as well as Interleukin-8\nrelease in HaCaT cells were observed. Finally, the inhibited growth of A375 melanoma nodules in the\nmelanoma skin model could be shown. Our results indicate that the OMWW extract is a promising\ningredient for dermal applications to improve skin health and skin protection as well as having a\npositive impact on skin ageing.
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